Vitamin Requirements for the Treatment of Hyperhomocysteinemia in Humans
We have previously shown that a modest vitamin supplement containing folic acid, vitamin B-12 and vitamin B-6 is effective in reducing elevated plasma homocysteine concentrations. The effect of supplementation of the individual vitamins on moderate hyperhomocysteinemia has now been investigated in a placebo-controlled study. One hundred men with hyperhomocysteinemia were randomly assigned to five groups and treated with a daily dose of placebo, folic acid (0.65 md), vitamin B-12 (0.4 mg), vitamin B-6 (10 mg) or a combination of the three vitamins for 6 weeks. Folic acid supplementation reduced plasma homocysteine concentrations by 41.7%, whereas the daily vitamin B-12 supplement lowered homocysteine concentrations by 14.8%. The daily pyridoxine dose did not reduce significantly plasma homocysteine concentrations. Read More.
We have previously shown that a modest vitamin supplement containing folic acid, vitamin B-12 and vitamin B-6 is effective in reducing elevated plasma homocysteine concentrations. The effect of supplementation of the individual vitamins on moderate hyperhomocysteinemia has now been investigated in a placebo-controlled study. One hundred men with hyperhomocysteinemia were randomly assigned to five groups and treated with a daily dose of placebo, folic acid (0.65 md), vitamin B-12 (0.4 mg), vitamin B-6 (10 mg) or a combination of the three vitamins for 6 weeks. Folic acid supplementation reduced plasma homocysteine concentrations by 41.7%, whereas the daily vitamin B-12 supplement lowered homocysteine concentrations by 14.8%. The daily pyridoxine dose did not reduce significantly plasma homocysteine concentrations. Read More.